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Cucumber Mosaic Virus Inducible Viral Amplicon (CMViva) Expression System

Technology Benefits

CMViva system using transient production: Short timeframe from gene to product Can use non-transgenic plant materials that might be available at a large scale and relatively inexpensive for recombinant protein production CMViva system using stably transformed cell cultures in bioreactors: Plant cells can be grown in inexpensive, chemically defined media devoid of any animal derived media components Containment which allows reproducibility and optimization of growth and induction conditions Ease of purification for secreted products Both methods provide: Production of safe human therapeutics and vaccines that are free from mammalian viruses/pathogens Production of proteins with post-translational modifications and complex glycosylation that is similar to mammalian systems.

Technology Application

Rapid, large-scale, and cost-effective production of functional human therapeutic proteins and vaccines or other commercially important proteins

Detailed Technology Description

Plant cell cultures and transgenic plants have been developing as a potential platform for production of recombinant proteins, particularly playing an increasingly important role in production of human therapeutics. However, efficient expression systems that can be tightly regulated are currently lacking for plant-based protein expression. Researchers at University of California, Davis have developed a novel protein expression system, called Cucumber Mosaic Virus Inducible Viral Amplicon (CMViva), to inducibly and efficiently produce recombinant proteins in transgenic plant cell cultures. This novel protein expression system can produce recombinant proteins in plant-based systems using either transient expression in whole plants, plant tissues or plant cell cultures (using wild type, non-transgenic host tissues), stably transformed plant cell cultures in bioreactors or in transgenic plants.

Supplementary Information

Patent Number: US20120005782A1
Application Number: US2009442395A
Inventor: McDonald, Karen A. | Dandekar, Abhaya | Falk, Bryce W. | Sudarshana, Mysore R. | Uratsu, Sandra L. | Plesha, Michael A. | Huang, Ting-kuo
Priority Date: 22 Sep 2006
Priority Number: US20120005782A1
Application Date: 10 Nov 2009
Publication Date: 5 Jan 2012
IPC Current: C12P002100 | A01H000500 | C12N000504 | C12N000900 | C12N001583
US Class: 800288 | 4350691 | 4350696 | 435183 | 4353201 | 435419 | 800298
Assignee Applicant: The Regents of the University of California
Title: CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM
Usefulness: CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM
Summary: The system and method are useful for expressing and producing heterologous protein (claimed).
Novelty: New chemically cucumber mosaic virus protein expression system, useful for expressing and producing heterologous protein