Optical Spectroscopy for the Detection of Ischemic Tissue Injury
Optical spectroscopy methods Fiber optic probes Able to target organs deep within a patient Non-invasive Non-traumatic Portable Measurements in a matter of seconds
Quantify ischemic tissue and organ injury Solid organ and tissue transplantation Civilian and battlefield trauma Ischemic bowel, cerebrovascular and cardiovascular disease Diabetic tissue injury
Several novel and distinct approaches to detect and quantify ischemic tissue damage have been developed by researchers at the University of California, Davis and the Lawrence Livermore National Laboratory (LLNL). Currently, physical examination and tissue biopsy remain the principal means of determining the viability of tissue that may be suffering from inadequate blood supply. Although symptoms of ischemic tissue damage are clinically relatively easily identified once they have occurred, significant problems prevent the detection of these symptoms in time to prevent permanent damage: Clinically apparent signs do not present themselves until a significant amount of tissue has been destroyed; Damage to internal organs requires extremely invasive examination procedures; and, Current detection methods are incapable of exactly locating the affected tissue. There is a substantial need to develop means of detecting and quantifying ischemic tissue damage in its early stages, before it is clinically apparent and before irreversible damage has occurred. This UC Davis and LLNL invention provides novel optical spectroscopy methods to quantify ischemic tissue and organ injury. These methods are non-invasive, non-traumatic, portable, and can make measurements in a matter of seconds. In addition, these methods can be realized through fiber optic probes, making it possible to take measurements of target organs deep within a patient’s body.
Patent Number: US7587236B2
Application Number: US200531936A
Inventor: Demos, Stavros | Fitzgerald, Jason | Troppmann, Christoph | Michalopoulou, Andromachi
Priority Date: 8 Jan 2004
Priority Number: US7587236B2
Application Date: 8 Jan 2005
Publication Date: 8 Sep 2009
IPC Current: A61B000600 | A61B000500 | G01N002149 | G01N002164
US Class: 600477 | 600473 | 600476
Assignee Applicant: Lawrence Livermore National Security LLC,Livermore
Title: Optical spectroscopy for the detection of ischemic tissue injury
Usefulness: Optical spectroscopy for the detection of ischemic tissue injury
Summary: For assessing tissue parameters for diagnosing injury of ischemic tissue in clinical environment, for assessment of tissue viability in organ transplant and for diagnosis of cerebrovascular disease, cardiovascular disease, diabetic tissue injury, ischemic bowel disease. Also for assessment of tissues in brain, kidney, liver, heart, bowel, stomach, skin, pancreas and muscles.
Novelty: Tissue parameter assessing method for ischemic tissue injury diagnosis, involves illuminating tissue region with light from electromagnetic radiation sources and detecting respective autofluorescences exhibited by illuminated region
Biomedical
Medical Imaging
Related Materials Tech ID/UC Case 11320/2004-313-0 Related Cases 2004-313-0
USA
