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Carrier Tests for Point-Restriction Coat Color in the Domestic Cat

Technology Benefits

Advantages of these carrier tests for coat color variants include: The ability to detect carriers of these specific DNA mutations at time of birth; Reduced need for expensive production of unwanted cats from test crosses; Non-invasive, lower cost DNA methods for diagnosis; Small required amount of DNA for testing; and More informed breeding decisions.

Technology Application

In these coat color carrier tests, these DNA mutations are used to detect carriers by DNA mutation testing. The mutations are recessive, thus carriers cannot be generally determined currently without test matings. DNA testing for these mutations can identify the carriers, reducing the need for expensive production of unwanted cats. In addition, the DNA testing can easily be performed on small amounts of DNA using very non-invasive and low cost collection techniques.

Detailed Technology Description

Novel carrier tests for Point-restriction and albinism in the domestic cat have been developed by University of California, Davis researchers. Three mutations cause four color variations that are presented in fancy breed and random bred cats throughout the world. These mutations have been identified in the gene Tyrosinase and are responsible for the "points" colorations, found in and distinguishing Siamese and Himalayan Persians, the Burmese coloration in Burmese and Singapura cats, and a complete albino phenotype found in Siamese and Colorpoints. The fourth coloration is due to a combination of “Points” and Burmese mutations, producing the phenotype in Tonkinese cats.

Supplementary Information

Patent Number: CN102071830B
Application Number: CN200910247112A
Inventor: LIN, Li | TENG, Jin-guang | YU, Tao
Priority Date: 19 Nov 2009
Priority Number: CN102071830B
Application Date: 19 Nov 2009
Publication Date: 11 Jul 2012
IPC Current: E04H001202
Assignee Applicant: The Hong Kong University of Science & Technology
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Industry

Agriculture

Sub Category

Animal

Application No.

7183058

Others

Related Materials

Lyons LA, Imes DL, Rah HC, Grahn RA. 2005. Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus). Anim Genet. 36(2):119-26.
Lyons LA, Foe IT, Rah HC, Grahn RA. 2005. Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mamm Genome. 16(5):356-66.
Also see The Lyons' Den at http://www.vetmed.ucdavis.edu/Catgenetics/Index.htm

Related Technologies

• Genetic Test for Determining Blood Type in Domestic Cats
• Tests for Polycystic Kidney Disease in Domestic Cats

Additional Technologies by these Inventors

• Genetic Test for Determining Blood Type in Domestic Cats
• Tests for Polycystic Kidney Disease in Domestic Cats

Tech ID/UC Case

11317/2004-427-0

Related Cases

2004-427-0

*Abstract

Carrier Tests for Point-Restriction and Albinism in the Domestic Cat

*IP Issue Date

Feb 27, 2007

*Principal Investigator

Name: Donna Imes

Department:

Name: Leslie Lyons

Department:

Country/Region

USA