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RNA Molecule for Precisely Regulating Gene Expression

IP Title: A Novel Hairpin mRNA Element for Regulation of Protein Translation

Detailed Technology Description: None

Application Date: May 16, 2014

Application No.: 10,006,049

Others

*Abstract

Boosts or Represses Gene Expression to Treat Diseases in Humans and Animals

This hairpin RNA molecule locates at the end of mRNA in the cell and controls its translation into proteins, enhancing control over gene expression when compared to available siRNA technologies. Controlling gene expression is an important aspect of gene therapy. Absent or abnormally functioning genes can be replaced, altered, or supplemented to treat disease and improve patient health. Existing technologies are only capable of repressing gene expression. Researchers at the University of Florida have developed an RNA molecule that can also increase gene expression levels. Animal testing has produced positive results. This RNA molecule could have many potential applications in gene therapy and other types of genomics research. The global gene therapy market is expected to reach $794 million by 2017.

Application

A hairpin-shaped RNA molecule for controlling gene regulation and treating diseases using gene therapy, which has proven successful in animals

Advantages

Boosts or represses gene expression, making it preferable to existing technologies that can only repress gene expression
Complements existing technologies, creating a wider portfolio of tools for researchers
Enables greater precision in regulating gene expression levels, providing more flexibility for research and treatment

Technology

Researchers have discovered an RNA molecule that affects gene expression rates. The RNA molecule locates at the end of the mRNA strand that will be translated into a protein. This prevents translation from occurring and lowers expression rates. Adding other proteins can modify the behavior of the mRNA to increase expression levels.

*IP Issue Date: Jun 26, 2018

*IP Publication Date: Apr 14, 2016

*Principal Investigator: Name: Chen Ling
Department:

Name: Arun Srivastava
Department:

Country/Region: USA

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