Ultra-low Power, Wireless Implantable Neural Electrode System
- IP Title
- Neural Interface Systems and Methods
- Detailed Technology Description
- None
- Supplementary Information
- Inventor: Benowitz, Larry I.
Priority Number: US6440455B1
IPC Current: C07H0019167 | A61K003152 | A61K003170 | A61K00317042 | A61K00317052 | A61K00317076 | A61K0031708 | A61P002500 | A61P002508 | A61P004300
US Class: 424450 | 424422 | 424423 | 424484 | 424486 | 424489 | 424490 | 424497 | 514045
Assignee Applicant: Children's Medical Center Corporation,Boston
Title: Methods for modulating the axonal outgrowth of central nervous system neurons
Usefulness: Methods for modulating the axonal outgrowth of central nervous system neurons
Summary: To modulate axonal outgrowth of CNS neurons, preferably stimulating or inhibiting the outgrowth. The method is particularly useful for stimulating axonal outgrowth following injury such as that due to stroke, traumatic brain injury, cerebral aneurysm, spinal cord injury (preferably monoplegia, diplegia, paraplegia, hemiplegia and quadriplegia) or for inhibiting axonal outgrowth in CNS neurons in patients suffering or prone to suffering from conditions characterized by increased axonal outgrowth of CNS neurons such as epilepsy, especially posttraumatic epilepsy, neuropathic pain syndrome. The method is useful in mammals, preferably humans, particularly for modulation of growth of CNS retinal ganglion cells.
Novelty: Modulating axonal outgrowth of central nervous system
- Industry
- Chemical/Material
- Sub Category
- Chemical/Material Application
- Application Date
- May 22, 2009
- Application No.
- 8,428,732
- Others
-
- *Abstract
-
Interfaces with Neural Tissue for Recording and Stimulation
This implantable neural electrode device serves as a potential therapy for patients suffering from a host of neurological disorders in the central or peripheral nervous system. According to a report by the World Health Organization, neurological disorders ranging from migraines to epilepsy and dementia, affect up to one billion people worldwide, and that number is expected to rise as populations age. Researchers at the University of Florida have developed a device that far surpasses any available therapy because it enables unprecedented miniaturization and minimal power consumption. This wireless, implantable system increases health safety and convenience compared to existing external, bulky devices.Applications
A technology in neuroprosthetics that serves as a potential therapy for patients suffering from a host of neurological disorders in the central or peripheral nervous system
Advantages
- Ability to be implanted under the skin, minimizing the risk of infection
- Increases mobility and convenience due to light weight and wireless capability
- Uses signal compression, which provides for long battery life and the ability to be recharged
- Capability of all components to be hybrid integrated on the same micro-machined substrate, minimizing fabrication costs
- Provides greater reliability and accuracy in signal recognition for longer periods of time, making it the most effective therapy available and providing a unique competitive advantage
Technology
This fully-integrated, implantable neural electrode system has low power consumption. The system utilizes an interface with neural tissue for recording, as well as stimulating, neural activity in a research subject or patient. With the use of the flexible substrate as a hybrid platform to integrate the electrodes, the amplification and signal processing electronics, and the wireless transmission and power management electronics, this therapy far surpasses anything currently available. The electrodes are integrated as a single unit with the flexible substrate while the electronics are optimized separately and then hybrid packaged. Constructing the component separately allows for more efficient and cost effective fabrication.
- *IP Issue Date
- Apr 23, 2013
- *IP Publication Date
- Nov 26, 2009
- *Principal Investigator
-
Name: Toshikazu Nishida
Department:
Name: John Harris
Department:
Name: Jose Principe
Department:
Name: Justin Sanchez
Department:
Name: Rizwan Bashirullah
Department:
- Country/Region
- USA
