Method of Forming Particles of Controllable Size Using Supercritical Fluids
The processes and methods involved in the invention can be used for producing nanoparticles of a wide variety of materials such as polymers, chemicals, pesticides, explosives, coatings, catalysts and pharmaceuticals. The invention relates to a method for the production of micron or nanometer size particles by precipitation, wherein a dispersion containing the substance of interest is contacted with a supercritical fluid antisolvent under near or supercritical conditions in order to maximize micro or nanoparticle formation. The invention also provides techniques to control the particle size, particle size distribution and particle morphology. The invention also includes supercritical fluid coating or composite material particle formation, wherein encapsulation of one substance by another substance or co-precipitation of more than one substance in the form of micro or nanoparticles are achieved in the supercritical fluid antisolvent.
USA