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Methods to Enhance RNAi Oligonucleotide Delivery to Respiratory Epithelial Cells
Detailed Technology Description
Description: This technology uses RNAi to reduce target mRNA to treat diseases in the pulmonary airway such as asthma, COPD, and Cystic Fibrosis. This has been shown to work in well-differentiated airway epithelial cells. The method involves contacting the cell with a sensitizing agent followed by contacting the cell with a therapeutic RNAi agent. This technology also includes a kit for reducing the level of a target mRNA by at least 1% and up to 50% in a well-differentiated PAE (porcine aortic endothelial) cell.
Country/Region
USA
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