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NS5A Effect on HIV Replication
Detailed Technology Description
Researchersat the University of Iowa have discovered a new peptide capable of preventingor treating HIV infections. The isolatedpeptide in NS5A is a small, non-structural protein that has been identified todecrease HIV infectivity of T-cells. This peptide encompasses a 15-80 amino acidregion of flaviviral NS5A that limits the entry point of lymphocytes from theHIV virus. NS5A limits the entry pointof HIV into T-cells in late stage infections. Further research has shown that NS5A (via expression of a GBV-C NS5Aphosphoprotein) is regulating the cell-mediated immune response against the HIVvirus.
Country/Region
USA
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