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Solution phase aptamer selection for challenging small molecule and biological targets

Summary

Oligonucleotide-based aptamers can selectively bind with high affinity to target molecules, and systematic evolution of ligands by exponential enrichment (SELEX) can be used to screen for and amplify the desired aptamer. However, some simple target molecules with few functional groups, like glucose and other monosaccharides, glycine, and fatty acids, have proven resistant to aptamer targeting. This technology is a method that utilizes organic reagents to improve the selective binding of DNA aptamers to simple targets. This technology has the potential to enable the use of aptamers to detect and analyze small molecules in situ.

Technology Benefits

Selects functional aptamers for challenging targetsIdentifies high affinity aptamer matches for compounds that have no known matches (e.g. glucose, amino acids, and fatty acids)Can be used to detect challenging targets in solution phaseGenerates physiologically relevant synapses between AD neurons.*Patent Information:Patent Pending (WO/2014/144744)Patent Pending (US 20160076021)Tech Ventures Reference: IR CU13095, CU15216

Technology Application

Development of aptamer-based sensorsClinical diagnostic toolsFood and beverage monitoringAllergen detectionFluorescence microscopyBasic research tool for organometallic-biomolecule reagent development

Detailed Technology Description

None

Country/Region

USA

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