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3D optical imaging with rapid, volume-based data acquisition at high spatiotemporal resolution

Summary

This technology is a 3D optical imaging system that enables simultaneous interrogation and monitoring of multiple local targets within a sample volume at high spatiotemporal resolution.

Technology Benefits

Provides high temporal resolution without compromising spatial resolutionEnables 3D imaging without mechanical motion, eliminating vibration error Capable of simultaneous photo-interrogation and monitoring of many targets within the sample volumeReduces photo-exposure via use of targeted illumination patternsCompatible with existing microscopes or as a stand-alone product

Technology Application

Three-dimensional microscopyHigh-frame-rate optical coherence tomographyFunctional imaging of neuronal activityMonitoring fluorescent signals indicative of cell-cell interactionsPotential monitoring of therapies that change the optical properties of tissuePhoto-stimulation of neuronal circuits using task-specific illumination patternsQuantification of neuronal activity in a 3D sample

Detailed Technology Description

None

*Abstract

None

*Inquiry

Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU13147

*Principal Investigator

*Publications

Packer AM, Peterka DS, Hirtz JJ, Prakash R, Deisseroth K, Yuste R. Two-photon optogenetics of dendritic spines and neural circuits. Nature Methods. 2012 Dec;9(12):1202-5.Nikolenko V, Watson BO, Araya R, Woodruff A, Peterka DS, Yuste R. SLM Microscopy: Scanless Two-Photon Imaging and Photostimulation with Spatial Light Modulators. Front Neural Circuits. 2008 Dec;2(5).Tech Ventures Reference:IR CU13147Licensing Contact: Beth Kauderer

Country/Region

USA