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High throughput method for identifying drug candidates for the treatment of neurodegenerative diseases

Technology Benefits

* Autonomous stem cell-derived neuron assay demonstrating biofidelity to neurodegenerative diseases* In vitro model for improved understanding of the genetic development of different neurodegenerative diseases* Rapid, high throughput screening for therapeutic targets * Validation testing of potential therapeutics## Patent Information:Patent Pending ([WO/2014/071042 A1]( http://patentscope.wipo.int/search/en/WO2014071042 ))Tech Ventures Reference: IR CU13092

Technology Application

* In vitro models for the study of ALS, Parkinson's disease, Huntington's disease, Friedreich's ataxia, or multiple sclerosis pathologies* High throughput screening of therapeutic targets for neurodegenerative diseases* Evaluation and selection of neurodegenerative disease therapeutics

Detailed Technology Description

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*Abstract

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*Inquiry

Jerry KokoshkaColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU13092

*Principal Investigator

*Publications

* [Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science, Vol. 321, Issue 5893, Jul 2008, pp.1218-21.]( http://goo.gl/2iEj1r )* [Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci, Vol. 10, Issue 5, Apr 2007, pp.615-22.]( )

Country/Region

USA