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Optical coherence tomography catheter for cardiac tissue imaging and characterization

Summary

Catheter-based cardiac surgery has become routine in standard clinical practice, allowing clinicians to probe the interior of the heart without an intensive surgical procedure. Although electrical mapping and force-based catheters have been developed for cardiac applications, the ability to extract structural and functional information from the targeted tissue remains limited. Optical coherence tomography (OCT) is an established imaging modality that so far has largely been used for high-resolution imaging of the retina. The technology presented here is an OCT-based imaging catheter for structural analysis of cardiac tissue. By incorporating OCT technology into a clinical, catheter-based system, interventional cardiologists may be able to leverage the high resolution capabilities of OCT to perform screening for endomyocardial biopsy (EMB) or to monitor the formation of ablation lesions.

Technology Benefits

High-resolution optical imagingIn situ tissue characterizationCatheter-based deployment method Real-time imaging capabilitiesPatent Information:Patent Pending (US 20160235303) Tech Ventures Reference: IR CU14027, CU14120

Technology Application

Screening technique for endomyocardial biopsyMonitoring of lesion formation during cardiac ablationCather-based OCT imaging systemOCT-guided surgical proceduresMinimally-invasive tissue characterization

Detailed Technology Description

None

*Abstract

None

*Inquiry

Richard NguyenColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

cu14027

*Principal Investigator

*Publications

Gan, Y., Fleming, C.P. “Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography” Biomed Opicst Express. 2013; 4(10):2150-65.Singh Moon, R., Hendon, CP. “Cardiac tissue characterization using near-infrared spectroscopy”. Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89263N. 2014.Singh-Moon RP, Marboe CC, and Hendon CP. “A near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation”. Biomedical Optics Express. 2015; 6(7): 2494-511.Yao X, Gan Y, Marboe CC, and Hendon CP. “Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography”. Journal of Biomedical Optics. 2016; 21(6): 061006.Gan Y, Tsay D, Amir SB, Marboe CC, and Hendon CP. “Automated classification of optical coherence tomography images of human atrial tissue”. Journal of Biomedical Optics. 2016; 21(10): 101407.

Country/Region

USA