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Focused ultrasound system for localized drug delivery across the blood brain barrier

Summary: Elisa E. Konofagou, Ph.D.

Technology Benefits: Minimally invasive due to transient creation of small BBB opening.Safe and quick relative to techniques such as cranial surgery.Non-toxic compared to drug-based methods for BBB disruption.Highly localized and cost-effective for access to specific regions of the brain.Enables single element transducer, MR guidance-free procedures.Patent information:Patent Pending (US 20090005711)Patent Pending (WO/2011/035312%20&maxRec=863))Patent Pending (WO/2011/079177%20&maxRec=868 ))Patent Pending (US 20110295105)Tech Ventures Reference: IR 2039

Technology Application: Recurrent drug delivery in Alzheimer's, Parkinson's and other central nervous system diseases.Localized delivery of toxic drugs to a tissue site of interest.Research tool for finely controlled membrane manipulation. High throughput drug screening in vivo.

Detailed Technology Description: Elisa E. Konofagou, Ph.D.

*Abstract: None

*Inquiry: Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 2039

*Principal Investigator

*Publications: Choi JJ, Wang S, Tung YS, Morrison B 3rd, Konofagou EE. "Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo," Ultrasound Med Biol. 2010 Jan;36(1):58-67.Y.S. Tung, F. Vlachos, J.J. Choi, T. Deffieux, K. Selert, E.E. Konofagou. In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol, Vol. 55, Issue 20, Oct 2010, pp. 6141-55.T.Deffieux, E.E.Konofagou. Numerical study of a simple transcranial focused ultrasound system applied to blood-brain barrier opening. IEEE Trans Ultrason Ferroelectr Freq Control, Vol. 57, Issue 12, Dec 2010, pp.2637-53.B. Baseri, J.J. Choi, T. Deffieux, M. Samiotaki, Y, Tung, O, Olumolade, S.A. Small, B. Morrison, E.E.Konofagou. Activation of signaling pathways following localized delivery of systemically-administered neurotrophic factors across the blood-brain barrier using focused ultrasound andmicrobubbles. Phys Med Biol, Vol. 57, Issue 7, April 2012, pp. N65-N81.

*Web Links: WIPOUSPTO: US20090005711A1

Country/Region: USA

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