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Small molecule inhibitor for more precise biotin/streptavidin tagging affords improved live cell imaging

Summary
Milan Stojanovic, Ph.D.
Technology Benefits
Significantly faster and cheaper method to produce monovalent streptavidin than other strategiesHighly compatible with nearly all commercially-available labeled or modified streptavidinImproves spatial resolution allowing usage in super resolution imaging methodsOligonucleotide backbone can be fully customizedInteractions with oligonucleotide backbone act as conditional switch that can free up one binding siteInhibitor itself can be tagged or labeled, if desiredPatent information:Patent Pending (WO/2013/036826Tech Ventures Reference: IR 2927
Technology Application
Improves biotin labeling for live-cell imaging by blocking crosslinkingCreates simple one-to-one biotin/streptavidin complex which simplifies analysisAllows biotin labeling to be used for direct counting quantificationImprovement of a biotin immobilization strategySensitive detection of RNA or DNABlock strategy can also be used to make smaller inhibitor that produces divalent streptavidin
Detailed Technology Description
Milan Stojanovic, Ph.D.
*Abstract
None
*Inquiry
Jerry KokoshkaColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
*IR
2927
*Principal Investigator
*Publications
S.K. Taylor, J. Wang, N. Kostic, M. N. Stojanovic. Monovalent Streptavidin that Senses Oligonucleotides. Angewandte Chem. Int. Ed., Vol. 52, Issue 21, May 2013, pp. 5509-5512.
Country/Region
USA

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