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Identification of rottlerin, a small molecule therapeutic for asthma with minimal side effects

Summary: Steven Marx, M.D.

Technology Benefits: Improves airway relaxation in response to ovalbumin and house dust-mite-induced asthma.Improves ability to treat chronic asthma symptoms by having minimal side-effects.Patent information:Patent Pending Tech Ventures Reference: IR CU14045

Technology Application: Therapeutic use against asthma.Use in other diseases where BK channel inhibition might be useful, such as diabetes, arterial hypertension, epilepsy and cancer.

Detailed Technology Description: Steven Marx, M.D.

*Abstract: None

*Inquiry: Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: CU14045

*Principal Investigator

*Publications: M.P. Goldklang, J.F. Perez-Zoghbi, J. Trischler, T. Nkyimbeng, S.I. Zakharov, T. Shiomi, T. Zelonina, A.R. Marks, J.M. D'Armiento, S.O. Marx. Treatment of experimental asthma suing a singla small molecule with anti-inflammatory and BK channel-activating properties. The FASEB Journal, Epub ahead of print, Aug. 2013.

Country/Region: USA

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