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Nanotechnology designed platform for DNA microarray applications using carbon nanotubes

Summary

Kenneth Shepard, Ph.D.

Technology Benefits

Improved yield and sensitivity due to real-time monitoring of conductance fluxes.Does not require labeling or significant sample preparation, like qPCR.In contrast to qPCR, thousands of gene targets can be tested at low levels of detection in parallel.In contrast to existing single-molecule detection systems, this technology does not rely on fluorescence.A smFET microarray is significantly more portable than qPCR unitsPatent information:Patent Pending

Technology Application

Can be used for label-free single-molecule detection.A new method for genomic diagnostics.Development of microarrays that can detect and quantify low levels of pathogenic DNA / RNAPotential design for a portable, low-cost option for point-of-care diagnosticsDesign of advanced high-throughput DNA sequencingStudy of chemical kinetics, reaction dynamics, biomolecular processes, biomolecule rotation on tethersAnalysis of water quality, other environmental monitoring.Food safety analysis and other microbial and public health risk assessments.

Detailed Technology Description

Kenneth Shepard, Ph.D.

*Abstract

None

*Inquiry

Jay HickeyColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU12289

*Principal Investigator

*Publications

S. Sorgenfrei, C.Y. Chiu, R. L. Gonzalez Jr., Y.J. Yu, P. Kim, C. Nuckolls, K.L. Shepard. Label-free single-molecule detection of DNA-hybridization kinetics with a carbon nanotube field-effect transistor. Nat. Nano., Vol. 6, Issue 2, Jan. 2011, pp. 126-132. Further Information: Columbia | Technology VenturesJay Hickey; Tel: (212) 854-6521Email: TechTransfer@columbia.edu

Country/Region

USA