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Nkx3.1/Pten Mutant Mice for the Study of Prostate Carcinogenesis

Technology Benefits: These mice provide a model system for the study of the early stages of human prostate carcinogenesis

Technology Application: The study of prostate carcinogenesisCharacterization of the early stages of carcinogenesisDevelopment of potential treatments for prostate cancer

Detailed Technology Description: The Nkx3.1 homeobox gene has restricted expression in the prostate and essential role in prostate differentiation and function. PTEN represents a frequent target of mutational inactivation in human cancers, and Pten heterozygous mutant mice develop c...

*Abstract: None

*Inquiry: Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 2737

*Principal Investigator

*Publications: Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Kim, MJ et al. (2002) PNAS. 99(5): 2884-2889

Country/Region: USA

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