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Photoactivated, localized drug delivery utilizing visible and infrared light

Summary: Light is a powerful pharmacological tool that can be used to selectively activate a photo-reactive drug in a specific location. This method, called photodynamic therapy, has been used successfully as a treatment for a variety of cancers including lung, pancreatic, esophageal, and skin cancers. However, most current photodynamic therapies require ultra-violet light, which has poor tissue penetration depths and can severely damage cells. This technology is a class of ruthenium-based tethers that can bind compounds and release them when exposed to visible or infrared light. It can be used to deliver a variety of biologically active molecules, including neurotransmitters, locally and selectively.

Technology Benefits: Visible and infrared light pose no risk to biological tissuesVisible and infrared light sources are inexpensive when compared to ultraviolet light sourcesAllows for precise control over drug deliveryCan be adapted for a wide range of drug-tether complexesPatent Information:Patent Pending (US 20120116287)Patent Pending (US 20080176940)Patent Pending (WO/2005/065192)Tech Ventures Reference: IR M09-102

Technology Application: Selective release of chemotherapeutic agentsSelective release of neurotransmittersSelective delivery of a variety of bioactive compounds Basic research tool for imaging and cell labeling

Detailed Technology Description: None

*Abstract: None

*Inquiry: Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: M09-102

*Principal Investigator

*Publications: Fino E, Araya R, Peterka DS, Salierno M, Etchenique R, and Yuste R. "RuBi-Glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines" Front. Neural Circuits, 2009 27 May;3(2)Salierno M, Marceca E, Peterka DS, Yuste R, Etchenique R. "A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes." J Inorg Biochem. 2010 Apr;104(4):418-22.Zayat L, Calero C, Alborés P, Baraldo L, Etchenique R. "A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage." J Am Chem Soc. 2003 Jan 29;125(4):882-3.Rial Verde EM1, Zayat L, Etchenique R, Yuste R. "Photorelease of GABA with Visible Light Using an Inorganic Caging Group." Front Neural Circuits. 2008 Aug 13;2:2.Zayat L1, Salierno M, Etchenique R. "Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines." Inorg Chem. 2006 Feb 20;45(4):1728-31.

*Web Links: WIPO: WO/2005/065192USPTO_1: US20080176940A1

Country/Region: USA

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