A diagnostic and therapeutic target for brain tumor
- Technology Benefits
- The technology provides a therapeutic target directly relevant to high-grade gliomas: new drug or treatment can be developed with fewer side effects and more efficiency and specificity; new diagnostic test can be developed with more accuracy.
- Technology Application
- The technology can used to develop novel diagnostic test for high-grade gliomas, based on the expression of the transcription factors The technology can used to develop specific therapy for high-grade gliomas by inhibiting or interfering the expression of the transcription factors
- Detailed Technology Description
- The technology identified a pair of transcription factors that are master regulators of the mesenchymal state of brain cells, which is responsible for the development of high-grade gliomas in humans. The technology showed that this pair of transcript...
- *Abstract
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None
- *Inquiry
- Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- 2584
- *Principal Investigator
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- *Publications
- Nature. 2010 Jan 21;463(7279):318-25.The transcriptional network for mesenchymal transformation of brain tumours. Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A.Columbia University Press-Release: Columbia Scientists Discover Two Genes That Drive Aggressive Brain Cancers
- Country/Region
- USA
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