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A novel anti-aging animal model using SIRT1 transgenic mice

Summary

Aging and aging-related diseases are fast becoming a widespread concern in most developed countries, contributing to increased pressure on healthcare providers and other social services. Currently, no drugs specifically aimed at extending the human lifespan are available. This technology is an anti-aging animal model that can be implemented in the discovery of new anti-aging drugs. This gain-of-function animal model provides researchers with an effective means of studying age-related disorders and evaluating therapeutic efficacy of novel anti-aging compounds.

Technology Benefits

Realistic replication and expression pattern of gene of interestEffectively evaluates active molecules in aging-related phenotype screensMimics effects of caloric restriction through SIRT1 activationUseful in vivo model for analyzing potential of small-molecule compounds for anti-agingTech Ventures Reference: IR 2142

Technology Application

Tool to study metabolic disease (i.e. diabetes)Tool to screen for new anti-aging compoundsTool to investigate the onset and pathobiology of age-related diseases (e.g. Alzheimer's, heart disease, stroke, cancer, etc.)

Detailed Technology Description

None

Country/Region

USA

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