Methods For Differentiating Insulin-producing Beta Cells from Pancreatic Precursor Cells
- Technology Benefits
- No need to rely on insulin producing cells isolated from the limited donorsPossibility of selecting the donor of the induced cells and thereby matching the recipientThe induced cells can be further manipulated to reduce immune rejectionThe cells to be implanted can be cultured and expanded to obtain necessary density for transplantationTransplant procedure is very similar to the pancreatic islets implantation protocolMuch shorter scheme to regenerate insulin producing cells, compared to therapy based on stem cells
- Technology Application
- Treatment of Type 1 diabetes due to the body's failure to produce insulinTreatment of Type 2 diabetes due to the body's diminished response to insulinThe factors responsible for differentiation can be used to grow beta cells
- Detailed Technology Description
- The technology presents a new method to grow insulin producing beta cells from pancreatic precursor cells. Factors that can direct the differentiation of non-insulin-producing precursor cells into insulin producing beta cells were found. The precurso...
- *Abstract
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None
- *Inquiry
- Sara GusikColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- 2026
- *Principal Investigator
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- *Web Links
- WIPO: WO/2008/063934
- Country/Region
- USA
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