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CMOS optical sensor microarray for biomolecular detection

Summary

Ken Shepard, Ph.D.

Technology Benefits

Much less expensive, smaller, and more portable than typical fluorescence based detectors.Captures fluorescence lifetime data, providing additional information regarding the analyte's environment.On-chip design eliminates losses associated with complex optical setups normally required for fluorescence detection; increases sensitivity.Multi-fluorophore detection without the need for multiple optical filters.Additional background rejection and eases requirements on optical filters.Utilizes CMOS biosensor chip that enables time-gated, time-solved fluorescence spectroscopy.Enables high frame rate FLIM imaging. Patent Information:Patent Published (US7738086)Tech Ventures Reference: IR M05-070

Technology Application

Self-contained DNA and protein microarrays for gene sequencing and protein detection.General fluorescent lifetime sensor for use with confocal microscopy system. Active microarrays and high frame rate imagers for fluorescence lifetime imaging microscopy.

Detailed Technology Description

Ken Shepard, Ph.D.

*Abstract

None

*Inquiry

Jay HickeyColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

M05-070

*Principal Investigator

*Publications

G. Patounakis, K.L. Shepard, R. Levicky. "Active CMOS Array Sensor for Time-Resolved Fluorescence Detection". IEEE Journal of Solid-state Circuts, Vol. 41, Issue 11, Nov. 2006, pp. 2521-2530.T.D. Huang, S. Sorgenfrei, P. Gong, R. Levicky, K.L. Shepard. "A 0.18-micron CMOS Array Sensor for Integrated Time-Resolved Fluorescence Detection". IEEE Journal of Solid-state Circuts, Vol. 44, Issue 5, May 2009, pp. 1644-1654.

*Web Links

USPTO: US20080037008A1

Country/Region

USA