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New fluorogenic substrates for monoamine oxidases
Technology Benefits
-- The technology highlights enzyme activity with greater sensitivity than other fluorogenic substrates because it emits at a range farther away from regions of autofluorescence.
Technology Application
-- The technology can be used for real-time monitoring of MAO activity (e.g., in neurotransmission) in intact neural tissue.-- The technology can be used for drug screening.
Detailed Technology Description
The technology is an efficient and selective fluorogenic reporter substrate for MAO-A and MAO-B. This substrate is based upon 6-aminocoumarin modified with an aminoethyl side chain. The technology relies upon a redox switch based on a sequence of oxi...
Country/Region
USA
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