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Plakophilin-1 (10B2) Monoclonal Antibody

Detailed Technology Description: Project #: D1995-20 Antigen Specificity: Plakophilin-1 Clone: 10B2 Specificity: Reacts with the N-terminus of human plakophilin-1 Host species: Mouse Reactive species: Human Description:Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Applications: Western blot, Immunofluorescence, Immunoprecipitation

*Abstract

*Principal Investigator: Name: Margaret Wheelock, Professor
Department: Biology

Name: James Wahl
Department: Department of Oral Biology

Name: Keith Johnson, Professor
Department: Oral Biology

Country/Region: USA

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