Enzyme-Linked Assay for Quantifying Polyphosphate in Biological Samples
- Detailed Technology Description
- Dr. Jim Morrissey from the University of Illinois has developed a microplate-based assay that allows identification and quantification of polyP in liquid biological samples such as plasma or serum.
- Countries
- Not Available
- Application No.
- None
- *Abstract
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Dr. Jim Morrissey from the University of Illinois has developed a microplate-based assay that allows identification and quantification of polyP in liquid biological samples such as plasma or serum. PolyP is a potent procoagulant moleculethat plays a role in the pathophysiology of many procoagulant and inflammatory diseases. Currently available methods to quantify polyP are difficult and extremely laborious, severely limiting their use in clinical studies. By using the strong interaction between polyethylenimine (PE) and polyP, the assay allows high- throughput quantification of medium and long-chain polyP in the low nM range, and shorter (platelet-size) polyP in the high nM range.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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