SerpinA1 Null Mouse as a Model for Alpha-one Antitrypsin Deficiency and Lung Conditions
- Detailed Technology Description
- The invention provides a novel mouse model with alpha-one antitrypsin deficiency for use as a tool to study lung conditions including emphysema. With the use of the recently developed CRISPR technolog
- Countries
- Not Available
- Application No.
- None
- *Abstract
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The invention provides a novel mouse model with alpha-one antitrypsin deficiency for use as a tool to study lung conditions including emphysema. With the use of the recently developed CRISPR technology, the inventors designed and implemented a strategy to delete all five copies of the SerpinA1 gene at once overcoming previous technical limitations preventing development of SerpinA1 null mice.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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