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Developing of Soluble FLT1 Targeting Therapeutics for Treatment of Preeclampsia

Detailed Technology Description
The invention comprises oligonucleotide compounds that bind intronic regions of mRNA encoding sFLT1 protein, thereby inhibiting expression of sFLT1 protein for treatment of preeclampsia and other angi
Countries
Not Available
Application No.
None
*Abstract

The invention comprises oligonucleotide compounds that bind intronic regions of mRNA encoding sFLT1 protein, thereby inhibiting expression of sFLT1 protein for treatment of preeclampsia and other angiogenic disorders. Targeting these regions with RNAi compounds enables selective silencing of truncated, soluble variants without interfering with regular FLT1 function. Further, there is no detectable transfer of the oligonucleotides to the fetus.

*IP Issue Date
None
*IP Type
Other Patent
Country/Region
USA

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