Zebrafish Etv2 Polyclonal Antibody
- Detailed Technology Description
- Background Etv2 (Ets variant 2) is a member of the ETS familyof transcription factors. ETStranscription factors play an essential role in embryonic vascular development,most being direct targets for endothelial gene expression. Recent studies have established Etv2 as the crucial,non-redundant regulator of embryonic endothelial specification anddifferentiation. Althoughvasculature has traditionally been studied in mammals, zebrafish provide anovel model for vascular research. Zebrafish offer the advantage of rapid development, embryo transparencyand many of the molecular players in vasculargenesis are functionallyconserved. Experimentsperformed in zebrafish first identified Etv2, demonstrating it as necessary andsufficient to induce the embryonic vascular endothelial program and establish that it isrequired for expression of several endothelial marker genes including Kdr,Fli1b and Flt4.Technology Dr. Lawson’s laboratory at UMass Medical School has developed thefirst antibody to recognize the zebrafish protein Etv2. This rabbit polyclonal antibody recognizesthe N-terminal end of the zebrafish Etv2 protein, providing specificrecognition of the protein without any cross-reactivity with other Etstranscription factors and the ability to immunologically monitor the expressionand localization of the protein, which was not previously possible. Competitive Advantages First available zebrafish antibody specific forrecognizing Etv2Antibody provides ability to immunologicallymonitor the expression and activity of Etv2Applications Immunoblot analysis Whole mount immunostaining Business Opportunity UMass OTM is seeking statements of interest fromparties interested in licensing to commercialize this technology.
- Countries
- Not Available
- Application No.
- None
- *Abstract
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- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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