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Netrin-1 antibody to block dependence receptors

Detailed Technology Description: This invention is a potential biologic therapy for certain cancers. Certain antibodies and peptides can block the tumour-promoting actions of the signal protein Netrin-1.

*Abstract: This invention provides peptides and antibodies which selectively block the cancer-promoting action of Netrin 1 by inhibiting activation of its receptor. This is based on Dr. Stetefeld's discovery that two specific parts of the Netrin 1 V2 subdomiain bind the NEO1/DCC and UNC5h2 receptors. This new understanding was used to design inhibiting peptides and antibodies.

*Inquiry: Odd Bres,Ph.D.TechnologyManagerPh:+1(204)474.9407Cell: +1(204)292.4238Email: odd.bres@umanitoba.ca

Country/Region: USA

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