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Novel Hydrogels with Controlled Degradation Properties for Biomaterials And Drug Delivery Devices

Detailed Technology Description: The invention provides a meansto selectively control the degradation rates of hydrogels and biconjugates,such as for drug release in the pharmaceutical industry or implants in thebiomaterials industry. Addition of thiols and maleimides is widely used in preparingbiological conjugates and is known to lead to some product instabilities in vivo, allowing the reverse reaction(retro Michael addition) to occur. By using a specific thiol in the process,the retro Michael addition can be rendered permanent at physiological pH andtemperature, introducing a novel technique for controlled degradation andrelease. Fig. Michael donor reactivity controls conversion under reducing conditions. Therefore, tuning and triggering of material properties is possible.

Countries: United States

Application No.: Patent Pending

*Abstract: None

*Inquiry: Denise M. BierleinUniversity of DelawareOffice of Economic Innovation and PartnershipsLicensing AnalystTelephone: (302) 831-4005Email: deniseb@udel.edu

*IP Issue Date: None

*IP Type: Provisional

Country/Region: USA

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