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Relay Electrospray Ionization - Ultrasmall Volume Analysis for Mass Spectrometry

Summary
Researchers at Purdue University have developed a new method of electrospray for ultrasmall volume sampling and analysis known as the relay electrospray ionization technique. The design is focused upon the on-demand injection of electrically charged ions onto the outside surface of a nanocapillary. The resulting passage of electrical charge from the injected ions to the substance creates an immediate electrospray from the capillary, resulting in no dead volumes. By moving secondary capillaries in an automated fashion, high throughput sample screening and analysis is enabled. Thus, the problems of the solution clinging to the apparatus, dead volume creation, the need for time consuming cleaning procedures to eliminate carryover, and small volume sampling are dealt with under this new system.
Technology Benefits
Samples exceptionally small amounts of matter accuratelyIntegrated, simplified small volume analysis On-demand, controlled chemical reactions in the primary and relay ion sources Eliminates carryover and time consuming cleaning procedures
Technology Application
Biology Chemical analysis Medical/Health
Detailed Technology Description
R. Graham CooksPurdue ChemistryAston Labs
Countries
United States
Application No.
None
*Abstract

*Background
Accurately assessing an extremely small quantity of a substance is a constant challenge for researchers in many fields, including biology and chemistry. Electrospray ionization is a well-established technique that has existed for decades and has applications in multiple fields, including mass spectrometry and material analysis/creation. The traditional method of electrospray ionization involves applying an electrical charge to a substance, which creates an aerosol of charged droplets of the substance that may then be analyzed. However, the electrical charge also creates opportunities for the solution to cling to the apparatus, creating dead volume, which may require time consuming cleaning procedures to eliminate carryover, making extremely small volume sampling difficult.
*IP Issue Date
None
*IP Type
Provisional
*Stage of Development
Process validation in lab
*Web Links
Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipR. Graham CooksPurdue ChemistryAston Labs
Country/Region
USA

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