Triggerable Oxygen Nanobubbles for Drug Delivery, Diagnosis, and Enhanced Survival
- Summary
- Researchers at Purdue University have capitalized on the broad clinical utility of ultrasound. This technology is the first nanosized oxygen- and cargo-bearing bubbles that can be tuned to first image at a low intensity and selectively release cargo upon an ultrasound trigger at a higher intensity.
- Technology Benefits
- Enhanced permeability and retention inside tumor vasculature.Controlled drug release Avoids immune system response. Transport of material through the encapsulating layer.
- Technology Application
- Pharmaceutical industryMedical/HealthcareCancer drug delivery and diagnosisTherapy for cancerous tumors
- Detailed Technology Description
- Joseph IrudayarajPhysiological Sensing FacilityBindley Bioscience CenterPurdue Agricultural & Biological Engineering
- Countries
- United States
- Application No.
- None
- *Abstract
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- *Background
- Ultrasound has a broad clinical utility in prostate cancer diagnosis because of its diagnostic capabilities, ease of use, portability, and ability to reveal fluid flow and structure of anatomy in vivo. Several commercial ultrasound contrast agents exist, but are synthesized using fluorinated gases or air and have sizes in the micron range. Past efforts have at most synthesized ~500 nm-sized particles and primarily functioned as a contrast agent. These large particles fail to take advantage of the enhanced permeability and retention (EPR) effect.
- *IP Issue Date
- None
- *IP Type
- Provisional
- *Stage of Development
- Proof of Concept
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipJoseph IrudayarajPhysiological Sensing FacilityBindley Bioscience CenterPurdue Agricultural & Biological Engineering
- Country/Region
- USA
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