AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.
Optimized 7-Azaindenoisoquinoline Topoisomerase I Inhibitors Anticancer Agent
Summary
Purdue University researchers have developed a novel process for synthesizing four TOP1 inhibitors and have optimized their structures for the greatest inhibitory activity and cytoxicity towards dividing cells. The compounds consist of 7-, 8-, 9-, and 10-azaindenoisoquinoline structures.
Technology Benefits
TOP1 is a proven target for cancer therapyAzaindenoisoquinolines have enhanced chemical stability and effectiveness over other TOP1 inhibitors
Technology Application
New cancer therapy drugsPharmaceutical industry
Detailed Technology Description
Mark CushmanPurdue Medicinal Chemistry and Molecular Pharmacology
Countries
United States
Application No.
8686146
Country/Region
USA
For more information, please click Here
