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7-Azaindenoisoquinolines as Anticancer Agents
Summary
Researchers at Purdue University have developed a series of 7-azaindenoisoquinoline derivatives that act to inhibit topoisomerase and subsequently induce cell death. This new class of topoisomerase inhibitors has the potential to possess enhanced chemical stability over traditional inhibitors, while increasing inhibitor effectiveness.
Technology Benefits
Azaindenoisoquinolines have enhanced chemical stability and effectiveness over other TOP1 inhibitorsTOP1 is a proven target for cancer therapy
Technology Application
Cancer TreatmentMedical/HealthcarePharmaceuticals
Detailed Technology Description
Mark CushmanPurdue Medicinal Chemistry and Molecular Pharmacology
Countries
United States
Application No.
8,686,146
Country/Region
USA
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