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Topoisomerase I Inhibitors Substituted with Carbohydrates

Summary

Researchers at Purdue University have developed a new topoisomerase I inhibitor that incorporates carbohydrate groups to increase solubility. The result is drug that is more bioavailable and stable, which comes with the added benefit of smaller doses acting more effectively. The synthetic route developed for these compounds is simple, versatile, and easily scalable. The newly synthesized compounds displayed potent anti-Top1 activity and ceased proliferation in transformed cells.

Technology Benefits

Carbohydrate-substituted indenoisoquinolines overcome common problems of solubility with this drug classTopoisomerase I is a proven target for cancer therapy

Technology Application

Cancer TreatmentMedical/HealthcarePharmaceuticalsDrug Development

Detailed Technology Description

Mark CushmanPurdue Medicinal Chemistry and Molecular Pharmacology

Countries

United States

Application No.

None

Country/Region

USA

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