Synthesis and Applications of Trifluoroacetate
- Summary
- Researchers at Purdue University have developed a new synthetic reagent and method for the mild and efficient preparation of fluorinated compounds. This simple and straightforward method can be accomplished by a novice chemist, at room temperature, in open air, and without the need for complicated inert atmosphere techniques. Among other intermediates, Purdue researchers validated this method through its use in the aldol and imino-aldol processes, the facile production of difluoroenolates, and the formation of alpha, alpha-difluorinated beta amino acids. Difluorinated molecules, such as beta amino acids, are important research tools and building blocks for drug discovery.
- Technology Benefits
- Novel trifluoroacetate release strategy uses mild conditions (room temperature)Generation of pharmaceutically important intermediates Compatible with large scope of substrates
- Technology Application
- Chemical AnalysisMedical/HealthcarePharmaceuticalsDrug Development
- Detailed Technology Description
- Colby GroupPurdue Chemistry
- Countries
- United States
- Application No.
- None
- *Abstract
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- *Background
- The incorporation of fluorine into fine chemicals has had a significant impact in the chemical, agrochemical, and pharmaceutical industries given nearly 20 percent of pharmaceuticals contain fluorine and significantly more agrochemicals contain fluorination. Fluoroform is a gas that is used in industrial processes, but it is a potent "greenhouse" gas. Because of this, the use of gaseous fluoroform must be strictly limited to prevent its unwanted escape into the atmosphere.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- *Stage of Development
- Prototype Testing
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipColby GroupPurdue Chemistry
- Country/Region
- USA
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