Stem Cell Therapy for Bladder Regeneration
- Technology Benefits
- Flexible scaffold that provideselasticityEnhanced regeneration of normalanatomy such as muscle, blood vessels and peripheral nervesDecreased chance of immuneresponse
- Detailed Technology Description
- New method for generating functional bladder tissue grafts from stem cells#therapeutics #stemcells #diseasemodel
- *Abstract
-
Northwestern scientists have developed a novel method for generating functional bladder tissue that can be used to treat a variety of bladder diseases by tissue grafting. The inventors grow a mixture of patients' stem cells a flexible scaffold material, which lowers the chance of rejection after grafting. Further, the elastic properties of the poly-(1,8)-octanediol co-citrate scaffold can mimic the behavior of healthy human bladder tissue. Another important advantage of this bladder repair method is that the tissue grafts generated from this proprietary combination of cells can promote regeneration of muscle, blood vessels and nerves that normally function in the bladder. Previous attempts at designing functional bladder tissues did not meet this important benchmark, so this invention could improve how bladder disorders are treated in the future.
- *Inventors
- Earl Cheng*Arun Sharma*Partha HotaNatalie FullerDerek MatokaMatthew Bury
- *Publications
- Sharma AK, Bury MI, Fuller NJ, Marks AJ,Kollhoff DM, Rao MV, Hota PV, Matoka DJ, Edassery SL, Thaker H, Sarwark JF,Janicki JA, Ameer GA, Cheng EY (2013) Cotransplantation with specificpopulations of spina bifida bone marrow stem/progenitor cells enhances urinarybladder regeneration, PNAS, 110:4003-4008.
- Country/Region
- USA
