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Human Lamin Expression Vectors

Technology Benefits: SimpleEfficient

Detailed Technology Description: Protein expression vectors for all three human nuclear lamin proteins #researchtool #gene

*Abstract: Northwestern scientists have developed protein expression vectors for recombinant production of nuclear lamins in Escherichia coli. There are at least 3 lamin proteins in human cells and together they accomplish several functions important for nuclear integrity, nuclear import and DNA replication. Because of these important functions, lamins have been extensively studied. These overexpression plasmids will facilitate research of lamins and enable generation of other research reagents as well.

*Inventors: Robert Goldman*Robert Moir

*Publications: Moir, RD, Lowy-Montag M,Goldman RD (1994) Dynamic Properties of Nuclear Lamins: Lamin B is Associatedwith Sites of DNA Replication. TheJournal of Cell Biology. 125: 1201-1212.

Country/Region: USA

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