Major Peptide Epitopes for the Pathogenic T Helper Cells of Human SLE
- Technology Benefits
- • Diminished severity of disease • Less toxic side effects
- Detailed Technology Description
- Very low dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T-cell subsets in a mouse model with potential human applications.#therapeutics #diseasemodel #autoimmunity #peptide
- *Abstract
-
Investigators at Northwestern University have identified peptides localized to distinct regions of histone proteins that are recognized by autoimmune T-cells in Systemic Lupus Erythematosus (SLE). These peptides, when administered in a mouse model of SLE, delay onset as well as significantly decrease the severity of the disease. The use of these peptides in the treatment of SLE would offer a more specific intervention by targeting the immune cells that mediate the pathogenic effects, but without the generalized immunosuppressive and toxic effects of the drugs currently being used. Importantly, these peptides appear to be effective even when the autoimmune disease is already established. The peptides can also be used as a sensitive diagnostic and/or prognostic tool for tracking autoimmune T-cells that may appear long before symptoms of the disease itself are manifested.
Also available: NU 2000-032
- *Inventors
- Syamal Datta* Arunan Kaliyaperumal
- *Publications
- 1. Kaliyaperumal, A., Mohan, C., Wu, W., andDatta, S.K.: Nucleosomal peptide epitopes for nephritis-inducing T helper cellsof murine lupus. J. Exp. Med.183:2459-2469, 1996. 2. Lu, L, Kaliyaperumal, A, Boumpas, D.T, Datta,S.K. Major peptide autoepitopes for nucleosome-specific T cells of human lupus.J. Clin. Invest. 104:345-355,1999.3. Kang,H.-K., Liu, M. and Datta, S. K. 2007. Low-dose peptide tolerance therapy oflupus generates plasmacytoid dendritic cells that cause expansion ofautoantigen-specific regulatory T cells and contraction of inflammatory Th17cells. (Selected for Cover Illustration). J. Immunol. 178: 7849-7858, 2007.4. Zhang, L., A. M. Bertucci, R. Ramsey-Goldman,R. K. Burt, and S. K. Datta. 2009. Regulatory T cell (Treg) subsets return inpatients with refractory lupus following stem cell transplantation, and TGF-b producing CD8+ Tregcells are associated with immunological remission of lupus. (Selected as “Must Read” for Faculty of 1000Medicine www.f1000medicine.com).5. Zhang L, Bertucci, M., Ramsey-Goldman R, Burt,R.K. and Datta SK. 2013. Major Pathogenic Steps in HumanLupus Can be Effectively Suppressed by Nucleosomal Histone PeptideEpitope-Induced Regulatory Immunity. 2013. Clin. Immunol. (accepted)
- Country/Region
- USA
