Interpenetrating Semi-Degradable Fibrin-Alginate Hydrogels
- Technology Benefits
- Semi-degradable Less rigid: More permissive environment for oocytes Alternative to ovarian tissue cryopreservation for cancer patients: No risk for reintroducing malignant cells Successful in vivo rodent model
- Detailed Technology Description
- Novel matrices that address a need for improved methods for fertility preservation.
- *Abstract
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Researchers in Lonnie Shea's laboratory have developed novel matrices that address a need for improved methods for fertility preservation. Their biological matrices are interpenetrating networks (IPNs) which are a combination of polymers in a network form. One polymer is synthesized and/or cross-linked in the presence of the other, either simultaneously or sequentially. In this particular invention, the IPN consists of fibrin, a biomatrix with multiple ECM components and entrapped growth factors, and alginate, a relatively inert scaffold which does not interact with integrins of mammalian cells. These unique matrices provide both the dynamic cell responsive properties and the needed physical support to create an environment supportive of in vitro ovarian follicle culture. The fibrin softens the more rigid alginate and is degradable over time to accommodate the growth and expansion of cells.
- *Inventors
- Lonnie Shea*Teresa Woodruff *Ariella Shikanov
- Country/Region
- USA
