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Stabilised peptides to Grb7 - A new oncology drug class/target

Detailed Technology Description: Targeting the Grb7 adaptor protein as a potential new target for the development of oncology drugs for tumours driven by epidermal growth factor receptor (EGFR) and/or ephrin receptors.

*Abstract: Monash University researchers are targeting the Grb7 adaptor protein as a potential new target for the development of oncology drugs for tumours driven by epidermal growth factor receptor (EGFR) and/or ephrin receptors. The team has created a library of stabilised peptides that specifically inhibit the activity of this protein in vitro and in cell assays, and have gained valuable structure/activity know-how of the target and compounds. This knowledge could form the basis of a development program forcreating novel, safe and effective anti-cancer drug compositions.

Country/Region: USA

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