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Compositions and Methods for Immunotherapy of Cancer and Infectious Diseases

Detailed Technology Description

Introduction A principal goal in the development of immunotherapies is to achieve a safe and effective activation of the immune system. One of the early signals of T lymphocyte and Natural Killer cell activation is the induction in expression of the cell surface glycoprotein CD69. This protein is involved in lymphocyte proliferation and functions as a signaling-transmitting receptor in these cells. Being able to regulate the expression of CD69 would be one significant step toward the development of an immunotherapy which would have broad reaching applications from cancer to infectious disease.    Description of Technology This technology is a recombinant protein known as Barrogen, derived from a bovine intestinal microorganism.. It is a vaccine adjuvant that has demonstrated effectiveness in human immune cell activation in vitro, with the added benefit of this response not being associated with pro-inflammatory cytokine production.   Key BenefitsActivation of T-cells and NK cells: enhanced expression of CD69 suggests an activated immune response of T lymphocytes and Natural Killer cells which will provide heightened defense against a variety of diseases such as cancer and infectious disease when used in immunotherapyNo association with pro-inflammatory cytokines-  cytokine levels are not elevated in response to human cells being treated with barrogen meaning potentially harmful inflammatory effects are not a concern ApplicationsImmunomodulationVaccine adjuvantProtein therapy Patent Status U.S. patent 7,393,534 Inventors Charles Aylsworth, David Juckett, Igor Zlatkin, Tatiana Zlatkin, John Judge, John Siu-Cheong Ho, Barnett Rosenberg Tech ID TEC2004-0006 Alternative contact due to temporary leave: Nina (Isi) Davis, Technology Marketing Manager, email: davisnin@msu.edu, phone (direct): (517)884-1829.

*Abstract

None

*Principal Investigator

Name: Charles Aylsworth, Retired

Department: Barros Research Institute

Name: David Juckett, Associate Director

Department: Office of Clinical Research

Name: Igor Zlatkin, Applicaton Scientist

Department:

Name: Tatiana Zlatkin

Department:

Name: John Judge, Research Assisant

Department: Bioeconomy Institute

Name: John Siu-Cheong Ho, Research Assistant Professor

Department: Biochemistry

Name: Barnett Rosenberg, Deceased

Department: Chemistry

Country/Region

USA