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Compounds for Cancer Therapy
Detailed Technology Description
These compounds are potent inhibitors of the isoenzyme PFKFB3,which is over-expressed to enhance glycolysis in most cancer cells. These newlyidentified inhibitors selectively bind to PFKFB3, reduce the Fru-2,6-BP levelsand glycolytic flux, resulting not only in growth inhibition of tumor cells butalso massive cell death. The compoundscan be administered to a patient by any suitable means, including intravenous,parenteral, subcutaneous, intrapulmonary, and intranasal administration.
Countries
United States
Application No.
13/467,764
Country/Region
USA
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