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Stable Polyelectrolyte Coated Nanoparticles

Technology Benefits

The approach:ΓÇóProvides a universal and an efficient platform for making stable drug colloidsΓÇóEnables an effective break down of drug particles into nano-size pieces, which are then prevented from self-aggregatingΓÇóIs associated with a higher loading efficacy as compared to conventional approachesΓÇóEffectively enables combination of two or more drugs into one nano-particleΓÇóWould be commercially useful for treatment/screening of variety of disorders such as breast cancer, prostate cancer, lung cancer, lymphomas, skin cancer, pancreatic cancer, colon cancer, melanoma, ovarian cancer, brain cancer, head and neck cancer, liver cancer, bladder cancer, non-small lung cancer, cervical carcinoma, leukemia, non-HodgkinΓÇÖs lymphoma, multiple sclerosis, neuroblastoma and glioblastoma, T and B cell mediated autoimmune diseases, inflammatory diseases, infections, hyper-proliferative diseases, AIDS, degenerative conditions, cardiovascular diseases, and transplant rejection

Detailed Technology Description

None

*Abstract

Most anti-cancer drugs are poorly-soluble in water. Many attempts have been made till date to load such poorly soluble drugs onto suitable pharmaceutical carriers such as liposomes, micelles, and oil-in-water emulsions. However, most of these approaches have been associated with limitations such as low loading efficacy (lower bioavailability) and larger particle size (200nmΓÇô300nm). This novel approach enables preparation of stable polyelectrolyte coated nanoparticles comprising high concentration of poorly soluble drugs, overcoming most prior-art limitations.

*Principal Investigator

Name: Yuri Lvov

Department:

Name: Vladmir Torchilin

Department:

Name: Zhiguo Zheng

Department:

Country/Region

USA