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Methods and Compositions for Generation of Developmentally-incompetent Eggs as Hosts for Nuclear, Spindle, or Pronuclear Transfer to Prevent Mitochondrial Disease Inheritance

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Methods and Compositions for Generation of Developmentally-incompetent Eggs as Hosts for Nuclear, Spindle, or Pronuclear Transfer to Prevent Mitochondrial Disease InheritanceDescription:METHODS AND COMPOSITIONS FOR GENERATION OF DEVELOPMENTALLY INCOMPETENT EGGS AS RECIPIENTS FOR TRANSFER OF NUCLEAR GENETIC MATERIALINV-14024INVENTORS: Jonathan Lee Tilly, Dori Cousins Woods Description Impaired egg mitochondria is associated with many developmental abnormalities such as embryonic growth arrest, implantation failure and miscarriage. Many assisted reproduction techniques have been used till date to ensure optimal mitochondrial functioning and improved success rates for fertilization. Such techniques involve e-nucleation (nucleus removal) of fertilized eggs, which could have otherwise developed into healthy embryos. As a result, such procedures/techniques are associated with many ethical issues. This invention discloses novel methods and compositions for generation and use of developmentally incompetent receipt eggs for transfer of nuclear genetic material, potentially addressing existing limitations and/or unmet needs.Value PropositionThe method/composition:ΓÇóSignificantly improves fertility outcomes for women seeking assisted reproductionΓÇóAllows for development of deactivated eggs that have no potential to undergo embryogenesisΓÇóAllows for e-nucleation (nucleus removal) of these cells followed by transfer of genetic material from the fertilized egg with impaired mitochondrial functionΓÇóEffectively optimizes energetic potential of embryos to improve pregnancy outcomesΓÇóEffectively prevents mitochondrial disease inheritance without ethical issues as observed conventionallyΓÇóWould be useful for the following commercial applications:oTreatment of mitochondrial associated infertilityoDevelopment of a genetically matched embryo free of mitochondrial diseases

Detailed Technology Description

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*Abstract

Impaired egg mitochondria is associated with many developmental abnormalities such as embryonic growth arrest, implantation failure and miscarriage. Many assisted reproduction techniques have been used till date to ensure optimal mitochondrial functioning and improved success rates for fertilization. Such techniques involve e-nucleation (nucleus removal) of fertilized eggs, which could have otherwise developed into healthy embryos. As a result, such procedures/techniques are associated with many ethical issues. This invention discloses novel methods and compositions for generation and use of developmentally incompetent receipt eggs for transfer of nuclear genetic material, potentially addressing existing limitations and/or unmet needs

*Principal Investigator

Name: Jonathan Tilly

Department:

Name: Dori Woods

Department:

Country/Region

USA