Flagellin-Based Vaccine Adjuvants
- Detailed Technology Description
- Flagellin may be delivered as a purified protein for its adjuvant effect.Alternatively flagellin can be delivered as flagellin-expressing cells, which continuously release flagellin for a period of time.Flagellin can be expressed by tumor-antigen presenting cells that are lethally irradiated, hence localizing and prolonging the T-cell activation effect for tumor antigens.Flagellin adjuvants may enhance therapeutic tumor vaccine efficacy for many tumor types, including leukemia and melanoma.
- *Abstract
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A barrier to the development of therapeutic cancer vaccines is tolerance of T-cells to tumor antigens.Flagellin is a bacterial protein that inhibits tolerance to tumor antigens, and can stimulate tumor antigen-presenting cells to activate T-cells.Experiments in mice in vivo show that flagellin induces the pro-inflammatory cytokine IL-12 and inhibits the anti-inflammatory cytokine IL-10, and inhibits tolerance to antigens.Flagellin may thus constitute an effective adjuvant to be administered with tumor vaccines to overcome tolerance.
- Country/Region
- USA
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