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Glycine alpha1 KK385 knockin mice

Detailed Technology Description
None
*Abstract
BackgroundAlcohol abuse and alcoholism are major health problems and one of the leading preventable causes of death. Before achieving better treatments for alcoholism, it is necessary to understand the critical actions of alcohol on membrane proteins that regulate fundamental functions in the central nervous system. The innovators generated a genetically modified knock-in (KI) mouse having a glycine receptor (GlyR) with phenotypical silent mutations at KK385/386AA, to studiy its cellular and in vivo ethanol sensitivity.AdvantagesThere are no currently available mouse lines with these mutationsMouse has significant lower sensititivy to ethanol Validated UsesWestern Blotting (Reference)ImmunocytochemistryReferenceReference: Neuropsychopharmacology. 2014 Oct;39(11):2538-48. doi: 10.1038/npp.2014.100. Epub 2014 May 7.Available for Non-exclusive Licensing
*Principal Investigator

Name: Luis Aguayo

Department:


Name: Gregg Homanics

Department: Med-Anesthesiology
Country/Region
USA

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