More Stable and Potent Cyclic ADP-Ribose Analogs
- Detailed Technology Description
- None
- *Abstract
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A potential method for enhancing the lifetime of bone marrow stem cells that uses cyclic ADP-ribose (cADPR) analogs has been developed. This technology works to increase the proliferation of human hemopoietic progenitor cells, more specifically to increase lymphocytes, in order to enhance the efficiency of the immune system without causing cell differentiation. This technologyΓÇÖs promotion of lymphocyte proliferation provides potential application in the treatment of cancer and other immunocompromised diseases such as AIDS.This technology more efficiently mobilizes intracellular calcium compared to other currently available methods. The cyclic ADP-ribose analogs are more stable to heat and enzymatic degradation than other corresponding cADPR analogs and have been found to be 50 to 100 times more potent than their parent molecules. Overall, the analogs are important research tools in examining the roles of cyclic ADP ribose in cellular function and may be important in the expansion of progenitor cells populations for bone marrow transplantation and gene therapy.
- *Principal Investigator
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Name: Timothy Walseth, Professor
Department: Department of Pharmacology
- Country/Region
- USA
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