Protein Separation Using Surface Modified Zirconium Oxide Particles
- Detailed Technology Description
- None
- *Abstract
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This system is based on high density zirconium oxide particles which can be used for target protein adsorption at high eluent flow rates and elevated temperatures than current polymer or silica based systems. This allows a faster separation of the target protein from the eluent. The target protein is adsorbed by the modified surface of the zirconia particles; surface modification can be selected based on the target protein. Removal of the target protein doesn't require reversing the flow of the eluent. A wide range of feedstocks containing the target protein can be used, including cells or cellular debris. The particles are stable at a low pH for sanitation using sodium hydroxide so the surface modification can be reapplied and reused.
- *Principal Investigator
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Name: Peter Carr, PhD, Professor
Department: Chemistry, College of Science and Engineering
- Country/Region
- USA
