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Time Resolved Liquid Jet Desorption Electrospray Ionization-Mass Spectrometry

Technology Benefits: ΓÇó Mass Spectrometry is used as the detector, which provides superior chemical specificity compared to spectroscopy techniques.ΓÇó Jet sample is being ionized, which provides high time resolution for the study of fast reaction kinetics.ΓÇó Helps to clarify the mechanisms of biochemical reactions.

Technology Application: The technology is best suited for analyzing biochemical reactions by companies that specialize in pharmaceutical development. Mass Spectrometry is a very large market that is continuing to grow. Mass Spectrometry is a $3 billion global market that consists of end-users in a vast array of industries and applications. The MS market is expected to see annual growth of better than 8% through 2010.

Detailed Technology Description: Stage of Development:A working prototype has been developed.Future Development:A higher time resolution in microsecond timescale is thought to be possible and is currently being tested. Also, other chemical and biological reactions are being explored for kinetics investigation.

*Abstract: At this time the predominant method for a pharmaceutical chemist characterizing reaction kinetics is to employ spectroscopy. The main issue with this technique is that spectrometry produces an absorption/emission spectrum and it is possible for multiple different compounds to have the same spectrum peak making it difficult to differentiate. Time-Resolved Liquid Jet Desorption Electrospray Ionization-Mass Spectrometry (DESI-MS) was developed to collect high time resolution and chemical specificity data in biochemical reactions by providing mass spectrometric analysis. A T mixer allows two separate chemicals in solution to be mixed together to form a free high-speed jet stream. Along the liquid jet, DESI spray ionizes the stream and the resulting ions are then monitored by the MS. The distance the jet travels is indicative of reaction time, so this technology is capable of collecting mass readings at different time points in the reaction.

*Principal Investigator: Name: Hao Chen, Ph. D and Zhixin Miao
Department:

Country/Region: USA

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